The Clinical Challenge & the cvi42 Solution

Executive Summary

Cardiovascular disease remains the leading cause of global mortality, yet diagnostic workflows remain fragmented. Traditionally, clinicians have been forced to navigate disconnected systems to assess a patient’s heart: one for anatomy (CCTA), another for function (CMR/Strain), and a third for vascular inflammation (PCAT/Plaque). This "siloed" approach creates diagnostic friction, increases costs, and delays life-saving interventions.

The Physician Perspective: Precision and Autonomy

For the radiologist and cardiologist, the transition to a unified platform offers three primary advantages:

1. Elimination of Diagnostic "Blind Spots": Traditional CCTA identifies stenosis (anatomy) but often fails to identify the vulnerability of a lesion. By integrating Plaque Analysis and PCAT (Pericoronary Adipose Tissue), physicians can identify active inflammation—the "hidden" driver of rupture—without leaving the workspace.
   
   
2. Workflow Continuity and Reduced Burnout: Jumping between disconnected systems leads to "swivel-chair" medicine. cvi42 integrates directly into existing PACS and reporting systems (like PowerScribe One) without expensive HL7 interface, allowing for high-throughput analysis that reduces the time from "scan to report".
   
   
3. Financial Sustainability and Reimbursement: With the 2026 transition to a Category I CPT code (75577) for AI-enabled quantitative plaque analysis, hospitals can now retain 70% of the technical and professional reimbursement fee. cvi42 enables the facility to perform these advanced analytics in-house, rather than outsourcing to costly third-party core labs who retain most of the reimbursement.

The Patient Impact & Strategic Outlook

The Patient Perspective: Safety and Certainty

From the patient's point of view, the diagnostic journey is often fraught with anxiety and repetitive testing. A unified workflow changes the experience fundamentally:

• The "One and Done" Experience: By assessing anatomy, function, and inflammation in a single sitting, patients avoid the "diagnostic odyssey" of stressful weeks spent waiting for multiple follow-up tests.
• Early Detection of the "Hidden" Risk: Many patients who appear "low risk" on standard CT scans harbor high levels of vascular inflammation. cvi42’s research capabilities—such as the analysis of pericoronary adipose tissue (PCAT) allows researchers to better understand these risks. This work is essential in the shift from reactive surgery to proactive prevention.
• Personalized Clinical Clarity: A patient is more likely to adhere to a treatment plan (statins, lifestyle changes) when they can see a unified, color-coded map of their own heart's health. cvi42 provides the visual evidence needed to drive patient compliance and trust.

Strategic Value for the Healthcare System

In a value-based care environment, the "All-in-One" approach of cvi42 serves the Quadruple Aim:

cvi42 empowers the clinical team to see the whole picture of Anatomy, Function, and Inflammation all in one place. This isn't just a software upgrade; it is a new standard of care for the modern heart center.

Strategic Financial Analysis: The Imaging Department & CFO Perspective

For an imaging department, by consolidating Anatomy, Function, and Inflammation into a single on-premise application, the institution secures immediate financial advantages through new reimbursement streams and significant operational efficiencies.

Revenue Capture: The 70% Retention Model



The primary financial catalyst is the 2026 activation of Category I CPT codes for AI-enabled quantitative plaque analysis. While traditional outsourcing models often result in the loss of technical fees to third-party labs, the cvi42 on-premise solution allows the hospital to maintain a commanding share of the revenue.

By keeping these advanced analytics in-house, the facility avoids the high costs of third-party processing, ensuring that approximately 70% of the total reimbursement remains within the hospital's bottom line.

Performance Improvements & Capacity Expansion

The unified workflow directly addresses "swivel-chair" medicine, where clinicians lose productive time navigating disconnected systems.

Summary of Strategic Financial Value



The future of cardiac care isn't just about faster software; it’s about providing a clearer picture of patient risk when it matters most. By bridging the gap between anatomy, function, and inflammation, cvi42 empowers clinicians to move beyond simple detection toward true prevention. As we transition into this new era of AI-enabled diagnostics and standardized reimbursement, the unified workflow stands as the new gold standard for heart health—transforming complex data into life-saving clinical confidence.